Movie S4

Spindly stably associates with the leading edge and to regions proximal to focal adhesions in migrating cells. U2OS stably expressing GFP-Spindly and transiently transfected with RFP-Zyxin were imaged in TIRF. Movie is shown at 600x realtime; field of view = 31.4 × 31.4 μm.

Spindly is required for rapid migration of human cells

Claudia Conte, Michelle A. Baird, Michael W. Davidson, and Eric R. Griffis

Biology Open 2018. 7:None-None; doi: 10.1242/bio.033233