Movie 1

Adult sh3pxd2bΔ/Δ fish develop fibrosis in their fins, affecting their swimming pattern. One-year-old sh3pxd2bΔ/Δ males (A) and females (B) develop gradually worsening fibrosis in the pectoral, dorsal, and anal fins, and the flank between the latter two fins, impairing movement of the affected fins.

The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome

Ivo J. H. M. de Vos, Arnette Shi Wei Wong, Jason Taslim, Sheena Li Ming Ong, Nicole C. Syder, Julian L. Goggi, Thomas J. Carney, and Maurice A. M. van Steensel

Biology Open 2020. 9:None-None; doi: 10.1242/bio.054270