Movie 2

Fissure formation in mESC-derived optic cup-like structure
4D analysis showed that a valley structure reminiscent of the embryonic optic fissure was self-formed in mESC-derived optic cup-like structure. Projection view (top left). Surface rendering (top right). Section view (bottom left). Total time: 33 hours.

Emergence of dorsal-ventral polarity in ESC-derived retinal tissue

Yuiko Hasegawa, Nozomu Takata, Satoru Okuda, Masako Kawada, Mototsugu Eiraku, and Yoshiki Sasai

Development 2016. 143:3895-3906; doi: 10.1242/dev.134601