To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Movie 2 Tg(fli1a:eGFP)y1 embryos were injected with plasmid expressing RFP or PKI-GFP fusion under control of endothelial fli1ep promoter and and growth and lumeniyation of ISVs were monitored from 29 till 45hpf. Time frame: 10min. cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner Pavel I. Nedvetsky, Xiaocheng Zhao, Thomas Mathivet, Irene M. Aspalter, Fabio Stanchi, Ross J. Metzger, Keith E. Mostov, and Holger Gerhardt Development 2016. 143:3582-3590; doi: 10.1242/dev.134767 Download Original Video