Movie 5

Prdm16-GOF cells show characteristic irregular migration, leading to the inhibition of CP invasion. IUE of control, CAG-Prdm16 or sh-Prdm16 was performed at E13.5. Cortical slices were prepared after 36 h and cultured under observation with a FV1000 confocal laser microscope. Time-lapse imaging data were then acquired automatically every 15 min for 29 h.

Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex

Mayuko Inoue, Ryota Iwai, Hidenori Tabata, Daijiro Konno, Mariko Komabayashi-Suzuki, Chisato Watanabe, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Fumio Matsuzaki, Koh-ichi Nagata, and Ken-ichi Mizutani

Development 2017. 144:385-399; doi: 10.1242/dev.136382