Movie 2

Clustering simulation based on a model of differential adhesion. Shows 48 hours of simulated clustering, sampled every 20 time steps. Only ureteric epithelium (adhesive) cells in a portion of simulation shown. Random colours are used to distinguish clusters, and similarity in colours between clusters has no meaning. See Fig. 4A, Fig. S2D-F and online methods for description and derivation of model. A cluster is defined as a set of cells where any two cells are connected by a path consisting of one or more adhesion bonds. Colour changes mark the joining of clusters; for example at 15 seconds the main black and blue clusters merge.

Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells

James G. Lefevre, Han S. Chiu, Alexander N. Combes, Jessica M. Vanslambrouck, Ali Ju, Nicholas A. Hamilton, and Melissa H. Little

Development 2017. 144:1087-1096; doi: 10.1242/dev.140228