Supplemental Movie 1
Notch signaling is active in the developing vasculature. Representative time-lapse confocal microscopy of a Tg(kdrl:mCherry); Tg(Tp1:VenusPEST) embryo treated with DMSO demonstrates Notch activity within the axial and sprouting vasculature (n=6). Embryos were mounted in E3 with tricaine. Treatment began at 18 ss, and continued, at RT, for 15 hours and 10 minutes. See Fig. S3 for still images.
Jason E. Fish, Manuel Cantu Gutierrez, Lan T. Dang, Nadiya Khyzha, Zhiqi Chen, Shawn Veitch, Henry S. Cheng, Melvin Khor, Lina Antounians, Makon-Sébastien Njock, Emilie Boudreau, Alexander M. Herman, Alexander M. Rhyner, Oscar E. Ruiz, George T. Eisenhoffer, Alejandra Medina-Rivera, Michael D. Wilson, and Joshua D. Wythe
2017. 144:2428-2444; doi: 10.1242/dev.146050