Supplemental Movie 2

Notch signaling is lost in the vasculature upon MAPK inhibition. Representative time-lapse confocal microscopy of a Tg(kdrl:mCherry); Tg(Tp1:VenusPEST) embryo treated with SL327 (30 uM) demonstrates reduced Notch activity within the vasculature, and decreased sprout elongation (n=6). Treatment began at 18 ss, and continued, at RT, for 15 hours and 10 minutes. See Fig. S3 for still images.

Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network

Jason E. Fish, Manuel Cantu Gutierrez, Lan T. Dang, Nadiya Khyzha, Zhiqi Chen, Shawn Veitch, Henry S. Cheng, Melvin Khor, Lina Antounians, Makon-S├ębastien Njock, Emilie Boudreau, Alexander M. Herman, Alexander M. Rhyner, Oscar E. Ruiz, George T. Eisenhoffer, Alejandra Medina-Rivera, Michael D. Wilson, and Joshua D. Wythe

Development 2017. 144:2428-2444; doi: 10.1242/dev.146050