Movie 2

Adult mutant islet whole-mount staining. Whole mount immunofluorescence of 8-week old mTOR mutant mice. Insulin is shown in green, emphasizing a loss of β cell mass in mutant animals. Movie was generated using Imaris software.

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets

Katie L. Sinagoga, William J. Stone, Jacqueline V. Schiesser, Jamie I. Schweitzer, Leesa Sampson, Yi Zheng, and James M. Wells

Development 2017. 144:2402-2414; doi: 10.1242/dev.146316