Movie 4

P21 Mutant islet whole-mount staining. Whole mount immunofluorescence of 3-week old mTOR mutant mice. Insulin is shown in green to highlight an elongated, dysmorphic islet at the center of the movie. Also present are smaller islets, which remain close to the ductal structures in mutant mice. Movie was generated using Imaris software.

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets

Katie L. Sinagoga, William J. Stone, Jacqueline V. Schiesser, Jamie I. Schweitzer, Leesa Sampson, Yi Zheng, and James M. Wells

Development 2017. 144:2402-2414; doi: 10.1242/dev.146316