Movie 8

Control PECs show higher proliferation rate than the CKO PECs.
Tbx18Cre/+; Cdc42fl/+; mTmG (control) and Tbx18Cre/+; Cdc42fl/fl; mTmG (CKO) hearts at E9.5 were fixed and whole mount stained for MF20, a marker for cardiomyocytes, and PH3, a marker for mitotic cells. Then the embryos were cleared and 3D imaged. The PE is shown section-by-section in each movie. Suppl. Movie 7 shows all sections of a control heart and suppl. Movie 8 shows all sections of a CKO heart.

CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane

Jingjing Li, Lianjie Miao, Chen Zhao, Wasay Mohiuddin Shaikh Qureshi, David Shieh, Hua Guo, Yangyang Lu, Saiyang Hu, Alice Huang, Lu Zhang, Chen-leng Cai, Leo Q. Wan, Hongbo Xin, Peter Vincent, Harold A. Singer, Yi Zheng, Ondine Cleaver, Zhen-Chuan Fan, and Mingfu Wu

Development 2017. 144:1635-1647; doi: 10.1242/dev.147173