Movie 1

Roll-over assay in notumKO null mutants
Individual wandering 3rd instar w1118 (left) and notumKO (right) on a 1% agarose-coated 100x15mm plate. Larvae were rolled over using a fine paintbrush, placing the ventral midline exactly upwards (t=0). A stopwatch was used to record righting time, until the dorsal midline was exactly upwards (time in the bottom right corner of the video).

Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling

Danielle L. Kopke, Sofia C. Lima, Cyrille Alexandre, and Kendal Broadie

Development 2017. 144:3499-3510; doi: 10.1242/dev.148130