Movie S2

CLARITY 3D reconstruction of Nrp2 knockout type whole pancreas at P1. Islets (glucagon, red; c-peptide, green) in Nrp2 knockout type pancreas form distinct small islets clusters, but also form large islet aggregates that are in close proximity to ductal structures (mucin, white). The 3D reconstruction movies were created in Arivis Vision4D software using data from Figure 4.

A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis

Philip T. Pauerstein, Krissie Tellez, Kirk B. Willmarth, Keon Min Park, Brian Hsueh, H. Efsun Arda, Xueying Gu, Haig Aghajanian, Karl Deisseroth, Jonathan A. Epstein, and Seung K. Kim

Development 2017. 144:3744-3754; doi: 10.1242/dev.148684