Movie S3
24 hour time-lapse video of endocrine cell migration and deformation in Nrp2 wild type embryonic pancreas explant. Endocrine lineage cells (red) in Nrp2 wild type pancreas (Nrp2+/+; Neurog3-tdTomato) readily display cell migration and cell deformation, such as filopodia extensions. Time-lapse video is created from data in Figure 5.
A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis
Development 2017. 144:3744-3754; doi: 10.1242/dev.148684