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Reaction-Diffusion model of free BMP4 distribution in differentiating hPSC colonies. The video shows the evolution of free BMP4 distribution in differentiating hPSC colonies in accordance with the BMP4-NOGGIN RD model in a differentiating colony of a 1000μm diameter.

A stepwise model of reaction-diffusion and positional information governs self-organized human peri-gastrulation-like patterning

Mukul Tewary, Joel Ostblom, Laura Prochazka, Teresa Zulueta-Coarasa, Nika Shakiba, Rodrigo Fernandez-Gonzalez, and Peter W. Zandstra

Development 2017. 144:4298-4312; doi: 10.1242/dev.149658

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