Movie 2
Reaction-Diffusion model of predicts BMPi = 50ng/ml would not generate periodic patterns of free BMP4 distribution in differentiating hPSC colonies of 3mm in diameter. The video shows the evolution of free BMP4 distribution in accordance with the BMP4-NOGGIN reaction diffusion model in differentiating hPSC colonies of 3mm in diameter when induced to differentiate with BMPi = 50ng/ml.
A stepwise model of reaction-diffusion and positional information governs self-organized human peri-gastrulation-like patterning
Development 2017. 144:4298-4312; doi: 10.1242/dev.149658