Movie 3

Reaction-Diffusion model of predicts induction of periodic waves of free BMP4 ligands distribution when hPSC colonies of 3mm in diameter are differentiated in BMPi = 200ng/ml. The video shows the evolution of free BMP4 distribution in accordance with the BMP4-NOGGIN reaction diffusion model in differentiating hPSC colonies of 3mm in diameter when induced to differentiate with BMPi = 200ng/ml.