Movie 2
Endothelial cells treated with Smad4 siRNA do not align and migrate against the direction of flow. Time-lapse movie (1 frame every 15 minutes) of HCAECs treated with Smad4-targeted siRNA subjected to shear stress at 35 dyne/cm2 for 72 hours. The direction of flow is left to right.
Endothelial cells respond to the direction of mechanical stimuli through SMAD signaling to regulate coronary artery size
Development 2017. 144:3241-3252; doi: 10.1242/dev.150904