Movie 1

Smad4 signaling in one- and two-cell ╬╝Colonies. BMP4 is added in frame 10. Time interval is 12 minutes. Total movie length is 17.4 hours (2 hours in MEF-CM alone and the remaining 15.4 hours - in MEF-CM + 10 ng/ml BMP4).

Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells

Anastasiia Nemashkalo, Albert Ruzo, Idse Heemskerk, and Aryeh Warmflash

Development 2017. 144:3042-3053; doi: 10.1242/dev.153239