Movie 6

Ex-vivo video-microscopy recording of ependymal cilia-generated CSF flow in the central aqueduct of a Ccdc39prh/prh mouse.
The P7 ependymal cilia of the Ccdc39prh/prh central aqueduct showing rigid axoneme and are unable to generate CSF fluid flow (video captured at a rate of 10.4 frames per second and played back at 5 frames per second). Scale bar is 10 μm.

A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice

Zakia Abdelhamed, Shawn M. Vuong, Lauren Hill, Crystal Shula, Andrew Timms, David Beier, Kenneth Campbell, Francesco T. Mangano, Rolf W. Stottmann, and June Goto

Development 2018. 145:None-None; doi: 10.1242/dev.154500