Movie 6
Ex-vivo video-microscopy recording of ependymal cilia-generated CSF flow in the central aqueduct of a Ccdc39prh/prh mouse.
The P7 ependymal cilia of the Ccdc39prh/prh central aqueduct showing rigid axoneme and are unable to generate CSF fluid flow (video captured at a rate of 10.4 frames per second and played back at 5 frames per second). Scale bar is 10 μm.
A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice
Development 2018. 145:None-None; doi: 10.1242/dev.154500