Movie 1
3-dimensional reconstruction of the dorsal aorta of an E10.5 Cre:cR1;cR1 embryo after initiation of ectopic Runx1 expression at E7.5. Sample is immunostained for CD31 (red), Runx1 (green) and Kit (cyan). Arrow points to an ectopic angiogenic sprout associated with hematopoietic cells.
Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis
Development 2018. 145:None-None; doi: 10.1242/dev.158162