Movie 2

3-dimensional reconstruction of the dorsal aorta of an E10.5 Cre:cR1;cR1 embryo after initiation of ectopic Runx1 expression at E7.5. Sample is immunostained for CD31 (red), Runx1 (green) and Kit (cyan). Arrow points to an ectopic extravascular island near the dorsal aorta.

Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis

Amanda D. Yzaguirre, Elizabeth D. Howell, Yan Li, Zijing Liu, and Nancy A. Speck

Development 2018. 145:None-None; doi: 10.1242/dev.158162