Movie 4
Additional expression of aPKC-DN or sif RNAi rescues the ectopic protrusions phenotype exhibited by patj RNAi expression. Reducing the function of aPKC (by aPKC-DN expression), or Sif (by sif RNAi expression), in the background of patj RNAi expression, rescued the phenotype of ectopic protrusions. Note that the leading protrusions are also significantly shortened. Scale bars: 10μm.
aPKC is a key polarity determinant in coordinating the function of three distinct cell polarities during collective migration
Development 2018. 145:None-None; doi: 10.1242/dev.158444