Wnt5aGOF hearts display morphological defects, reduced ventricular trabeculation and increased percentage of NkxECs. Embryonic hearts from control (left) and Wnt5aGOF (right) hearts were isolated at e12.5, serially sectioned and imaged by confocal microscopy. Nuclei (blue), VEGFR2GFP+ ECs (green) and Nkx2.5Cre:tdTomato+ cells (red) are shown.
David E. Reichman, Laura Park, Limor Man, David Redmond, Kenny Chao, Richard P. Harvey, Makoto M. Taketo, Zev Rosenwaks, and Daylon James
Development
2018. 145:None-None; doi: 10.1242/dev.159905