Movie 7

Wnt5aGOF hearts display morphological defects, reduced ventricular trabeculation and increased percentage of NkxECs. Embryonic hearts from control (left) and Wnt5aGOF (right) hearts were isolated at e12.5, serially sectioned and imaged by confocal microscopy. Nuclei (blue), VEGFR2GFP+ ECs (green) and Nkx2.5Cre:tdTomato+ cells (red) are shown.

Wnt inhibition promotes vascular specification of embryonic cardiac progenitors

David E. Reichman, Laura Park, Limor Man, David Redmond, Kenny Chao, Richard P. Harvey, Makoto M. Taketo, Zev Rosenwaks, and Daylon James

Development 2018. 145:None-None; doi: 10.1242/dev.159905