Movie 23

Cdc42FIL/POL:WT sprout
Simulation movie showing a 1:1 Cdc42FIL/POL:WT sprout in which the green and red cells respectively depict Cdc42FIL/POL and WT cells. The green Cdc42FIL/POL cells extend less filopodia, are less polarized and are less competent to occupy the tip position than the red WT cells. The Cdc42FIL/POL and WT cells both segregate vertically and horizontally. The green layer underneath the vessel shows the VEGF gradient, which linearly increases towards the tip.

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations

Bàrbara Laviña, Marco Castro, Colin Niaudet, Bert Cruys, Alberto Álvarez-Aznar, Peter Carmeliet, Katie Bentley, Cord Brakebusch, Christer Betsholtz, and Konstantin Gaengel

Development 2018. 145:None-None; doi: 10.1242/dev.161182