Movie 24
Cdc42COR:WT sprout
Simulation movie showing a 1:1 Cdc42COR:WT sprout in which the green and red cells respectively depict Cdc42COR and WT cells. The green Cdc42COR cells extend less cortical protrusions and are less competent to occupy the tip position than the red WT cells. The Cdc42COR and WT cells thus segregate horizontally but not vertically. The green layer underneath the vessel shows the VEGF gradient, which linearly increases towards the tip.
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations
Development 2018. 145:None-None; doi: 10.1242/dev.161182