Cdc42ADH:WT sprout
Simulation movie showing a 1:1 Cdc42ADH:WT sprout in which the green and red cells respectively depict Cdc42ADH and WT cells. The green Cdc42ADH cells are more strongly adhesive and consequently less motile which renders them less able to occupy the tip position than the red WT cells. The Cdc42ADH and WT cells thus segregate horizontally but not vertically. The green layer underneath the vessel shows the VEGF gradient, which linearly increases towards the tip.
Bàrbara Laviña, Marco Castro, Colin Niaudet, Bert Cruys, Alberto Álvarez-Aznar, Peter Carmeliet, Katie Bentley, Cord Brakebusch, Christer Betsholtz, and Konstantin Gaengel
Development
2018. 145:None-None; doi: 10.1242/dev.161182