Movie 9

Animation of continuous optical ZYX sections of blood vessels at the sprouting front (allowing a view into the vessel lumen) of P7 retinas. The image sequence is oriented proximal to distal with the first frame being located at more mature vessels of the sprouting front and the last frames ending with endothelial tip cells. Blood vessels stained with CD31 antibody (white). Vascular lumen of the sprouting front in control (Movie 9) and Cdc42iΔEC retinas (Movie 10)

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations

Bàrbara Laviña, Marco Castro, Colin Niaudet, Bert Cruys, Alberto Álvarez-Aznar, Peter Carmeliet, Katie Bentley, Cord Brakebusch, Christer Betsholtz, and Konstantin Gaengel

Development 2018. 145:None-None; doi: 10.1242/dev.161182