Movie 7

Injection of FN-MO together with KD-Pak1 mRNA leads to rapid collapse of lamellipodia. In this time lapse recording cells in the aggregate form large lamellipodia which rapidly switch to filopodia extension, and retreat, leaving retraction fibers behind.

PDGF-A suppresses contact inhibition during directional collective cell migration

Martina Nagel, and Rudolf Winklbauer

Development 2018. 145:None-None; doi: 10.1242/dev.162651