Movie 3

Rac1 activity in migrating endodermal cells in control and gpc4 mutant embryos.
Representative time-lapse movies of anterior endoderm in control (left panel) or gpc4 mutant (right panel) host embryo transplanted with sox32, PDB-GFP-expressing and rhodamine-labeled control (left panel) or gpc4 mutant (right panel) cells. Images were acquired at 10-sec intervals using a Ziess LSM700 confocal microscope with a LD C-Apo 40×/NA 1.1 water objective and movie plays at 5 frames/sec.

Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition

Bo Hu, Yuanyuan Gao, Lauren Davies, Stephanie Woo, Jacek Topczewski, Jason R. Jessen, and Fang Lin

Development 2018. 145:None-None; doi: 10.1242/dev.163303