Movie 12

Timelapse of cell movements in the ptch2tc294z mutant (12-24 hpf). Marked cells originate from a region that should contribute to the ventronasal optic cup and nasal margin of the optic fissure. Cells exit the midline region, initially exhibit an elongated morphology, but then take on an aberrant morphology and contribute to the optic stalk region. Maximum intensity projection of photoconverted Kaede (grayscale) to visualize entire cell morphologies. Time interval between z-stacks, 2.75 minutes. Dorsal view.

Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis

Hannah B. Gordon, Sarah Lusk, Keith R. Carney, Emily O. Wirick, Brooke Froelich Murray, and Kristen M. Kwan

Development 2018. 145:None-None; doi: 10.1242/dev.165068