Movie 17

Timelapse of ptch2tc294z mutant donor cells in a wild type host. Donor cells (magenta) originating in the midline region move through the prospective optic stalk and into the optic cup. Cells exhibit a bipolar morphology and one cell contributes to the optic fissure margin. Maximum intensity projection of donor cells (magenta, fluorescent dextran lineage tracer) superimposed on average projection of host membrane label (green, Tg(bactin2:EGFPCAAX)). Time interval between stacks, 8.8 minutes. Dorsal view.

Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis

Hannah B. Gordon, Sarah Lusk, Keith R. Carney, Emily O. Wirick, Brooke Froelich Murray, and Kristen M. Kwan

Development 2018. 145:None-None; doi: 10.1242/dev.165068