Movie 4

Segmentation of ptch2tc294z mutant optic cup to visualize disrupted optic fissure morphology. Lateral view of 3-dimensional volume rendering of manually segmented optic cup (teal), lens (gray), and optic stalk (gold), 24 hpf. The optic fissure has not formed correctly; there are no obvious, closely apposed margins in the ventral optic cup.

Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis

Hannah B. Gordon, Sarah Lusk, Keith R. Carney, Emily O. Wirick, Brooke Froelich Murray, and Kristen M. Kwan

Development 2018. 145:None-None; doi: 10.1242/dev.165068