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Cranial neural tube closure is disrupted by zinc deficiency.
Zinc deficiency induced by treatment with 15μM TPEN at the start of imaging of a 9 somite VenMyr mouse embryo causes failure fo cranial neural tube closure and significant reduction in head size (n=6).

Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation

Huili Li, Jing Zhang, and Lee Niswander

Development 2018. 145:None-None; doi: 10.1242/dev.169797