Movie 5

Inhibition of p53 mitochondrial pathway with pifithrin-μ does not rescue neural tube closure.
Culture of a 9 somite VenMyr mouse embryo with both 15μM TPEN and 50μM pifithrin-μ, an inhibitor of p53 mitochondrial function, does not rescue TPEN-induced failure of neural tube closure (n=5).

Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation

Huili Li, Jing Zhang, and Lee Niswander

Development 2018. 145:None-None; doi: 10.1242/dev.169797