Movie 2

Detail of nuclear apical migration in apoptotic cells. Nuclei marked in green indicate DBS-S activation, LifeAct-Ruby shows actin in red. The time-lapse is showing a cross-section of a wing imaginal disc. Notice the progressive accumulation of GFP signal in the nuclei, the changes in their shape (roundness increase) and the movement towards the apical cell cortex. Notice also the contraction of the actin bundles over time (blue arrowheads). The recording started 90 minutes after irradiation and it lasted for 40 minutes. Snapshots were acquired every 2 minutes.

Novel initiator caspase reporters uncover previously unknown features of caspase-activating cells

Luis Alberto Baena-Lopez, Lewis Arthurton, Marcus Bischoff, Jean-Paul Vincent, Cyrille Alexandre, and Reuben McGregor

Development 2018. 145:None-None; doi: 10.1242/dev.170811