Movie 5

Knocking down genes encoding WNT and NOTCH pathway components leads to distinct signature phenotypes in the Germ Layer and Morphogenesis strains. Movie presents side-by-side views of development in the Germ Layer (left) and Morphogenesis (right) strains for a control embryo (top) along with embryos in which genes encoding components of the WNT (lit-1, wrm-1) or NOTCH (lag-1, aph-1) signaling pathways have been knocked down. Images were acquired every 20 minutes. Playback is 7200X real time.

A high-content imaging approach to profile C. elegans embryonic development

Shaohe Wang, Stacy D. Ochoa, Renat N. Khaliullin, Adina Gerson-Gurwitz, Jeffrey M. Hendel, Zhiling Zhao, Ronald Biggs, Andrew D. Chisholm, Arshad Desai, Karen Oegema, and Rebecca A. Green

Development 2019. 146:None-None; doi: 10.1242/dev.174029