Movie 3

After injury, macrophage-lineage cells rapidly migrate towards the site of brain injury. The movie shows maximum intensity projections of z-stacks of the optic tectum in an injured mpeg1:GFP animal, revealing rapid directional movement of macrophage-lineage cells towards the lesion site after brain injury. The traces indicate cell body displacement of individual cells in the 140 min following injury. Scale bar, 40 μm.

Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo

Chiara Herzog, Laura Pons Garcia, Marcus Keatinge, David Greenald, Christian Moritz, Francesca Peri, and Leah Herrgen

Development 2019. 146:None-None; doi: 10.1242/dev.174698