Movie 7

Microglial uptake of cellular debris is reduced in adgrb1a/b crispants. In a mpeg1:GFP animal injected with adgrb1a/b gRNAs, a microglial cell extends a process towards a PI+ cell but does not proceed to phagocytose it. The movie was recorded from 30 to 66 min following injury. Scale bar, 15 μm.

Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo

Chiara Herzog, Laura Pons Garcia, Marcus Keatinge, David Greenald, Christian Moritz, Francesca Peri, and Leah Herrgen

Development 2019. 146:None-None; doi: 10.1242/dev.174698