Movie 1

Live imaging of migrating cortical interneurons in an E14.5 Dlx5/6-CIE brain slice under control conditions. Ventrolateral left, dorsomedial right. Movie Clip 1. Mid-cortical position of an E14.5 Dlx5/6-CIE brain slice imaged for 12 hours in control conditions. Cortical interneurons predominately migrate tangentially in MZ and SVZ streams as they advance across the cortex. Some cells travel diagonally or radially to switch streams, but rarely stop in the cortical plate region. Movie Clip 2. Three tracked cortical interneurons originating in the SVZ maintain their tangential orientation and remain in the SVZ stream for the duration of the recording.

JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons

Abigail K. Myers, Jessica G. Cunningham, Skye E. Smith, John P. Snow, Catherine A. Smoot, and Eric S. Tucker

Development 2020. 147:None-None; doi: 10.1242/dev.180646