Movie 4

Wild-type embryo at 80% epiboly. DIC time-lapse imaging of hypoblast/mesendodermal cells located 90° from the notochord and near the embryo equator as shown in Fig. 2A (15 min time-lapse/30 s imaging intervals). Anterior is to the top and dorsal to the right. Select bleb protrusions are highlighted with arrowheads.