Movie 5

Computer model simulations of cranial neural crest cell migration with AQP-1 manipulation. (top) Control migration is modeled by normal cell speed and unstable filopodia. (middle) AQP-1 loss-of-function is modeled by reduced cell speed and reduced number of cell filopodia. (bottom) AQP-1 gain-of-function is modeled by increased cell speed, stable cell filopodia and tunneling. Each simulation is run on a 2D migratory domain.