Movie 5

Computer model simulations of cranial neural crest cell migration with AQP-1 manipulation. (top) Control migration is modeled by normal cell speed and unstable filopodia. (middle) AQP-1 loss-of-function is modeled by reduced cell speed and reduced number of cell filopodia. (bottom) AQP-1 gain-of-function is modeled by increased cell speed, stable cell filopodia and tunneling. Each simulation is run on a 2D migratory domain.

Neural crest cells bulldoze through the microenvironment using Aquaporin 1 to stabilize filopodia

Rebecca McLennan, Mary C. McKinney, Jessica M. Teddy, Jason A. Morrison, Jennifer C. Kasemeier-Kulesa, Dennis A. Ridenour, Craig A. Manthe, Rasa Giniunaite, Martin Robinson, Ruth E. Baker, Philip K. Maini, and Paul M. Kulesa

Development 2020. 147:None-None; doi: 10.1242/dev.185231