Movie 3

2-D numerical simulation of Model C. This movie shows a 2-D numerical simulation of Model C within an explant-shaped domain. The initial distal-high to proximal-low Pax6 pattern is dynamically re-polarised, generating a graded expression along the explant’s longest axis. This long axis could represent the optic vesicle’s former Anterior-Posterior axis (as labelled) or Dorsal-Ventral axis. The movie shows the evolving concentration patterns of all six molecular species represented in the model.

The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network

Timothy Grocott, Estefania Lozano-Velasco, Gi Fay Mok, and Andrea E. Münsterberg

Development 2020. 147:None-None; doi: 10.1242/dev.185827