Movie 2
RhoGEF2 photo-activation results in a spatially controlled increase of mechanical tension at apical and basal cell edges.
Time-lapse movies of wing discs expressing RhoGEF2-CRY2 and CIBN::pmGFP under the indicated control and experimental conditions. Time relative to laser ablation of a single cell edge is shown. Cell membranes are visualized by GAP43::mCherry. Red dots indicate the two vertices of the ablated cell edge; red lines indicate positions of laser cuts. Scale bars: 10 μm.
Increased lateral tension is sufficient for epithelial folding in Drosophila
Development 2020. 147:None-None; doi: 10.1242/dev.194316