Movie 4.

MCC deficiency causes blastomere asymmetry. Besides abnormal divisions, BUB1B-injected bovine embryos often exhibited blastomere asymmetry following the multipolar cleavage.

Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development

Kelsey E. Brooks, Brittany L. Daughtry, Brett Davis, Melissa Y. Yan, Suzanne S. Fei, Selma Shepherd, Lucia Carbone, and Shawn L. Chavez

Development 2022. 149:None-None; doi: 10.1242/dev.198341