Movie 4

Endodermal cells display junctional changes but not polarized cellular protrusions during endoderm C&E in gpc4-/- mutant embryos during 7-12s. Confocal time-lapse experiment was performed on gpc4-/-/Tg(sox17:memGFP/H2AmCherry) embryos using the same settings with that in Movie 1 and the movie plays at 4 frames/sec. Labeling in this movie is the same as that of Movie 1.

Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2

Anurag Kakkerla Balaraju, Bo Hu, Juan J. Rodriguez, Matthew Murry, and Fang Lin

Development 2021. 148:None-None; doi: 10.1242/dev.199421