Movie 5

Endodermal cells extended lamellipodia in random directions in gpc4-/- embryos at 7-12s. Confocal time-lapse experiment was performed on gpc4-/-/Tg(sox17:memGFP) embryos using the same settings with that in Movie 2 and the movie plays at 4 frames/sec. Labeling in this movie is the same as that of Movie 2.

Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2

Anurag Kakkerla Balaraju, Bo Hu, Juan J. Rodriguez, Matthew Murry, and Fang Lin

Development 2021. 148:None-None; doi: 10.1242/dev.199421