Movie 3.

McSCs generate progeny Time-lapse video of a Tg(crestin:mCherry;mitfa:GFP) embryo during McSC regeneration (DMSO control). Embryos were treated with MoTP to kill differentiated melanocytes and initiate melanocyte regeneration. McSCs were followed for over 14 hours (post MoTP washout). McSCs are crestin+ mitfa-low, but then during or shortly after cell division, a cell strongly expresses GFP+ to become a mitfa-high cell, which then leaves the McSC compartment and migrates towards the epidermis.

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells

Hannah Brunsdon, Alessandro Brombin, Samuel Peterson, John H. Postlethwait, and E. Elizabeth Patton

Development 2022. 149:None-None; doi: 10.1242/dev.200277