Movie 2.
Time-lapse lineage tracing of EHT in dnmt1 atgMO-injected embryos. The fate transition via EHT was impaired in dnmt1 morphant Tg(kdrl:mCherry/cmyb:EGFP) embryo from 34 hpf to 40 hpf. The white arrow indicates the HEC and emerging HSPC.
DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling
Development 2022. 149:None-None; doi: 10.1242/dev.200390