Movie 1.
Exemplary heart phenotypes of kcnh6a-inception editants 10 second movies of heart beat and heart morphology analysis at stage 35 of wildtype (WT, left) and kcnh6a-inception injected embryos. Representative phenotypes cover 2:1 atrioventricular block (middle) and reduced ventricular contractility (right). A, atrium; V, ventricle; movie plays at 10 frames per second (real time).
De novo PAM generation to reach initially inaccessible target sites for base editing
Development 2023. 150:None-None; doi: 10.1242/dev.201115