Movie 1.

Exemplary heart phenotypes of kcnh6a-inception editants 10 second movies of heart beat and heart morphology analysis at stage 35 of wildtype (WT, left) and kcnh6a-inception injected embryos. Representative phenotypes cover 2:1 atrioventricular block (middle) and reduced ventricular contractility (right). A, atrium; V, ventricle; movie plays at 10 frames per second (real time).

De novo PAM generation to reach initially inaccessible target sites for base editing

Kaisa Pakari, Joachim Wittbrodt, and Thomas Thumberger

Development 2023. 150:None-None; doi: 10.1242/dev.201115